Compuestos Naturales y de Síntesis - Evaluación de Bioactividad

Proyectos

• Fortalecimiento de la convivencia y vida universitaria Mi UV «Club de juegos de mesa» (2024). Patrocinante
• Fondo de Apoyo a la Mantención y Proyección de Líneas de Investigación Puente UV «Desarrollo de fármacos antiparasitarios: Diseño racional y síntesis de cumarinas como inhibidores de la enzima GAPDH en Trypanosoma cruzi» (2024). Director
• Fondo de Investigación para académicas y académicos recientemente instalados INICI-UV «Chemical-biological study (in vitro and in vivo) of new analogues of triazolopyridines as anti-Trypanosome cruzi, the effect on sterol pathways» (2023). Director
• FONDECYT de Iniciación en Investigación 11180712 «Chemical and biological study (in vitro and in vivo) of new analogues of triazolopyridines as anti-Tripanosoma cruzi , the effect on sterol pathways» (2018). Investigador responsable.
• FONDECYT Postdoctorado 3160022 «Estudio del mecanismo de acción de una nueva familia de cumarinas como agentes tripanocidas a través de un análisis metabolómico» (2015). Investigador responsable.

Publicaciones

• Moncada-Basualto M, et al. Assessment of the Activity of Nitroisoxazole Derivatives against Trypanosoma cruzi. Molecules 2024, 29(12), 2762 10.3390/molecules29122762
• Quintero-Pertuz H, et al. Trypanocidal effect of alcoholic extract of Castanedia santamartensis (Asteraceae) leaves is based on altered mitochondrial function. Biomedicine and Pharmacotherapy 2022, 148, 112761 10.1016/j.biopha.2022.112761
• López-Lira C, et al. New benzimidazolequinones as trypanosomicidal agents. Bioorganic Chemistry 2021, 111, 104823 10.1016/j.bioorg.2021.104823
• Rodriguez Arce E, et al. New heterobimetallic ferrocenyl derivatives are promising antitrypanosomal agents. Dalton Trans 2019, 48, 7644-7658 10.1039/c9dt01317b
• Lapier M, et al. Novel [1,2,3]triazolo[1,5-a]pyridine derivatives are trypanocidal by sterol biosynthesis pathway alteration. Future medicinal chemistry 2019, 11, 10 10.4155/fmc-2018-0242
• Toro PM, et al. Condensation and substitution products obtained in reactions of isomeric bromo-nitrofuraldehydes with ferrocenylamine: Electrochemistry and anti-parasitic evaluation. Journal of Organometallic Chemistry 2019, 901, 120946 10.1016/j.jorganchem.2019.120946
• Leal D, et al. Chemical structure and biological properties of sulfated fucan from the sequential extraction of subAntarctic Lessonia sp (Phaeophyceae). Carbohydrate polymers 2018, 199, 304-313 10.1016/j.carbpol.2018.07.012
• Moncada-Basualto M, et al.  Supramolecular hydrogels of β-cyclodextrin linked to calcium homopoly-l-guluronate for release of coumarins with trypanocidal activity. Carbohydrate polymers 2018, 204, 170-181 10.1016/j.carbpol.2018.10.010
• Rojas DA, et al. Endogenous overexpression of an active phosphorylated form of DNA polymerase β under oxidative stress in Trypanosoma cruzi. PLoS neglected tropical diseases 2018, 12(2): e0006220 10.1371/journal.pntd.0006220
• Moncada-Basualto M, et al. Evaluation of Trypanocidal and Antioxidant Activities of a Selected Series of 3-amidocoumarins. Medicinal chemistry 2018, 14(6), 573 – 584 10.2174/1573406414666180419113437
• Lapier M, et al. Evaluation of the Novel Antichagasic Activity of [1,2,3]Triazolo[1,5-a]pyridine Derivatives. Current topics in medicinal chemistry 2017, 17(4), 399-411 10.2174/1568026616666160824103040
• Rpdroguez-Arce E, et al. Rhenium(I) tricarbonyl compounds of bioactive thiosemicarbazones: Synthesis, characterization and activity against Trypanosoma cruzi. Journal of inorganic biochemistry 2017, 170,125-133 10.1016/j.jinorgbio.2017.01.011
• Maya JD, et al. Chronic Chagas cardiomyopathy: A therapeutic challenge and future strategies. Emerging Topics in Life Sciences 2017, 1(6): 579–584. 10.1042/ETLS20170109
• Robledo-O’Ryan N, et al. Synthesis, antioxidant and antichagasic properties of a selected series of hydroxy-3-arylcoumarins. Bioorganic & medicinal chemistry 2016, 25(2),621-632 10.1016/j.bmc.2016.11.033
• Seguel V, et al. Pentamidine antagonizes the benznidazole’s effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target. Experimental parasitology 2016, 171,23-32 10.1016/j.exppara.2016.10.007
• Urra FA, et al. Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation. Toxicology and applied pharmacology 2015, 291, 46-57 10.1016/j.taap.2015.12.005
• Campos-Estrada C, et al. Simvastatin and Benznidazole-Mediated Prevention of Trypanosoma cruzi-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin. PLoS neglected tropical diseases 2015, 9(5), e0003770 10.1371/journal.pntd.0003770

Identificador ORCID 0000-0002-1327-1964