Compuestos Naturales y de Síntesis

Proyectos

• Nodos de Innovación UV «Adquisición de equipo homogeneizador de alta presión y accesorios para trabajo en formulados nano» (2022). Coinvestigador
• FONDECYT Postdoctorado 3220105 «Sintesis de nuevos analogos de brasinoesteroides de cadena corta tipo 23,24-dinorcolano con esteres de benzoato 2,4 disustituidos y estudio de su actividad promotora del crecimiento vegetal» (2022). Investigador patrocinante
• Concurso de Investigacion en Docencia Universitaria UV «Maleta didactica tipo ABP para fortalecer la enseñanza de estereoisomeria en quimica organica» (2022). Coinvestigador
• FONDECYT Regular 1231502 «Design and synthesis of new brassinoesteroids analogs with benzoate groups at C-22. Assessment of effects on plant growth, and in silico studies of structure activity relationship» (2021-2024). Coinvestigador
• FONDECYT Regular 1201395 «Drimanic sesquiterpens and lichen metabolites as building block for the synthesis of new sesquiterpene-orcinol derivatives, as potential topoisomerase I/ II, and or PDK1 kinase inhibitors» (2019-2022). Investigador responsable

Publicaciones

• Jorquera S, et al. Novel brassinosteroids analogues with 3,6 dioxo function, 24-nor-22(S)-hydroxy side chain and p-substituted benzoate function at C-23-synthesis and evaluation of plant growth effects. International Journal of Molecular Sciences 2024, 25:7515 10.3390/ijms25147515
• Montenegro I, et al. Antimicrobial Activity of Drimanic Sesquiterpene Compounds from Drimys winteri against Multiresistant Microorganisms. Molecules 2024, 29(12), 2844 10.3390/molecules29122844
• Tapia E, et al. Effect of Cannabis sativa L. extracts, phytocannabinoids and their acetylated derivates on the SHSY-5Y neuroblastoma cells’ viability and caspases 3/7 activation. Biological Research 2024, 57(33). 10.1186/s40659-024-00506-0
• Aitken V, et al. New Brassinosteroid Analogs with 23,24-Dinorcholan Side Chain, and Benzoate Function at C-22: Synthesis, Assessment of Bioactivity on Plant Growth, and Molecular Docking Study. International Journal of Molecular Sciences 2024; 25(1), 419. https://doi.org/10.3390/ijms25010419 
• Araque I, et al. Cytotoxic Activity, Topoisomerase I Inhibition and In Silico Studies of New Sesquiterpene-aryl Ester Derivatives of (-) Drimenol. Molecules 2023; 28(9):3959. 10.3390/molecules28093959
• Bustos L, et al. Cytotoxic Effects on Breast Cancer Cell Lines of Chalcones Derived from a Natural Precursor and Their Molecular Docking Analysis. Molecules 2022, 27(14), 4387 10.3390/molecules27144387
• Espinosa-Bustos C, et al. New Amino Naphthoquinone Derivatives as Anti-Trypanosoma cruzi Agents Targeting Trypanothione Reductase. Pharmaceutics 2022, 14(6): 1121 10.3390/pharmaceutics14061121
• Mellado M, et al. QSAR-driven synthesis of antiproliferative chalcones against SH-SY5Y cancer cells: Design, biological evaluation, and redesign. Archiv der Pharmazie 2022, 355:e2200042. 10.1002/ardp.202200042
• Mellado M, et al. Combined 3D-QSAR and docking analysis for the design and synthesis of chalcones as potent and selective monoamine oxidase B inhibitors. Bioorganic Chemistry 2021, 108:104689 10.1016/j.bioorg.2021.104689
• Ferrer K, et al. Synthesis of New Brassinosteroid 24-Norcholane Type Analogs Conjugated in C-3 with Benzoate Groups Molecules 2021, 26(4), 1173. 10.3390/molecules26041173
• Madrid A, et al. Chemical Analysis and In Vitro Bioactivity of Essential Oil of Laurelia sempervirens and Safrole Derivatives against Oomycete Fish Pathogens. Molecules 2021, 26(21), 6551. 10.3390/molecules26216551
• Ogalde JP, et al. Análisis nutricional del maíz lluteño y caracterización de los ácidos grasos en muestras antiguas y modernas del norte de Chile. Interciencia: Revista de ciencia y tecnología de América 2020, 45(12)
• Mellado M, et al. Design, synthesis, antifungal activity, and structure–activity relationship studies of chalcones and hybrid dihydrochromane–chalcones. Molecular Diversity 2020 10.1007/s11030-019-09967-y 
• Mellado M, et al. Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity. Chemistry Select 2019, 4, 7698. doi.org/10.1002/slct.201901282
• Russo A, et al. Antigrowth activity and induction of apoptosis in human melanoma cells by Drymis winteri forst extract and its active components. Chemico-Biological Interactions 2019, 25;305:79-85. 10.1016/j.cbi.2019.03.029.
• Quiñones N, et al. (-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of angucyclinones. Molecules 2018, 23(6), 1422 10.3390/molecules23061422
• Montenegro I, et al. Antifeedant effect of polygodial and drimenol derivatives against Spodoptera frugiperda and derivatives against Spodoptera frugiperda and Epilachna paenulata and quantitative structure-activity analysis.  Pest Management Science 2018, 74(7):1623-1629 10.1002/ps.4853
• Montenegro I, et al. Biopesticide Activity from Drimanic Compounds to Control Tomato Pathogens. Molecules 2018, 23(8), 2053. 10.3390/molecules23082053
• Mellado M, et al.  Synthesis of chalcones with antiproliferative activity on the SH-SY5Y neuroblastoma cell line: Quantitative Structure–Activity. Medicinal Chemistry Research 2018, 27, 2414–2425 10.1007/s00044-018-2245-2
• Mellado M, et al. Hansch’s analysis application to chalcone synthesis by Claisen–Schmidt reaction based in DFT methodology. Chemical papers 2018, 72, 703-709 10.1007/s11696-017-0316-3
• Apablaza G, et al. 2D-QSAR and 3D-QSAR/CoMSIA Studies on a Series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-Phenylethan-1-ol with Human β3-Adrenergic Activity. Molecules 2017, 22(3), 404. 10.3390/molecules22030404
• Madrid A, et al. Chemical Characterization and Anti-Oomycete Activity of Laureliopsis philippianna Essential Oils against Saprolegnia parasitica and S. australis. Molecules 2015, 20(5), 8033-8047. 10.3390/molecules20058033
• Taborga L, et al. Antiproliferative effect and apoptotic activity of linear geranylphenol derivatives from phloroglucinol and orcinol. Chemico-Biological Interactions 2016, 247,22-29. 10.1016/j.cbi.2016.01.016
• Flores S, et al. Synthesis and Evaluation of Novel Oxyalkylated Derivatives of 2′,4′-Dihydroxychalcone as Anti-Oomycete Agents against Bronopol Resistant Strains of Saprolegnia sp. International Journal of Molecular Sciences 2016, 17(8), 1366. 10.3390/ijms17081366
• Cuellar M, et al. Preliminary Studies on the Synthesis of (-)-Shikimic Acid Based 1, 2, 3, 4-Tetrahydrobenzo [b] phenanthridine-7, 12-diones. Synlett 2015, 26(04), 552-556. 10.1055/s-0034-1379948
• Montenegro I, et al. Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines. Molecules 2014, 19(11), 18993-19006. 10.3390/molecules191118993
• Quiñones N, et al. 2-Phenylaminonaphthoquinones and related compounds: Synthesis, trypanocidal and cytotoxic activities. Bioorganic & Medicinal Chemistry 2014, 22(17), 4609-4620. 10.1016/j.bmc.2014.07.030
• Cuellar M, et al. Depsides and triterpenes in Pseudocyphellaria coriifolia (lichens) and biological activity against Trypanosoma cruzi. Natural Product Research 2013, 27(17), 1607-1610. 10.1080/14786419.2012.740033
• Quiñones N, et al. Synthesis of a New ent-Cyclozonarone Angular Analog, and Comparison of Its Cytotoxicity and Apoptotic Effects with ent-Cyclozonarone. Molecules 2013, 18(5), 5517-5530. 10.3390/molecules18055517

Presentaciones en congresos

• XXXIV Jornadas Chilenas de Química. Póster «Synthesis and cytotoxicity activity of new sesquiterpene-aryl derivatives of (-)drimenol». Puerto Varas, Chile. Enero 2024
• X Jornadas de Innovación Curricular y Buenas Prácticas Pedagógicas. Póster «Maleta didáctica de tipo ABP para fortalecer la enseñanza de estereoisomería en química orgánica» 2023
• 1er Congreso 2023 ConRedSup Investigación en Docencia y Educación Superior en América Latina. Presentación oral «Maleta didáctica de tipo ABP para fortalecer la enseñanza de estereoisomería en química orgánica» 2023
• XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, España. Presentación oral «Síntesis de nuevos sesquiterpen-polifenoles, actividad citotóxica y estudios de acoplamiento molecular inducido (Docking)» 2022
• XLIII Congreso Anual de la Sociedad de Farmacología de Chile (SOFARCHI), Punta Arenas, Chile. Póster «Cytotoxic activity and Topoisomerase I inhibition of new sesquiterpene/phenol derivatives from drimenol» 2022
• Innovation in Natural Products-based Biopesticides and Drugs from Agroforestry Waste, Plants and Microorganisms, Universidad de Granada, España. Exposición oral «Sesquiterpenos del Canelo (Drimys winteri), base estructural para la obtención de compuestos bioactivos» 2021
• II Congreso Iberoamericano de Química de Productos Naturales. Presentación «Obtención y caracterización de metabolitos liquénicos de Pseudocyphellaria compar con potencial  antimicrobiano» 2021